Fractalkine/CX3CR1 signaling during neuropathic pain
نویسندگان
چکیده
منابع مشابه
Fractalkine/CX3CR1 signaling during neuropathic pain
Chronic pain represents a major problem in clinical medicine. Whilst the acute pain that is associated with tissue injury is a protective signal that serves to maintain homeostasis, chronic pain is a debilitating condition that persists long after the inciting stimulus subsides. Chronic neuropathic pain that develops following damage or disease of the nervous system is partially treated by curr...
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Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We wil...
متن کاملACUPUNCTURE AND NEUROPATHIC PAIN About neuropathic pain
Neuropathic pain results from damage to, or dysfunction of, the system that normally signals pain. The International Association for the Study of Pain (IASP 2007) defines neuropathic pain as follows: ‘Pain initiated or caused by a primary lesion or dysfunction in the nervous system. Peripheral neuropathic pain occurs when the lesion or dysfunction affects the peripheral nervous system. Central ...
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Ildiko Racz,1* Xavier Nadal,3* Judith Alferink,1,2* Josep E. Baños,3 Jennifer Rehnelt,1 Miquel Martín,3 Belén Pintado,5 Alfonso Gutierrez-Adan,5 Elena Sanguino,6 Nicolas Bellora,4 Jorge Manzanares,6 Andreas Zimmer,1 and Rafael Maldonado3 1Institute of Molecular Psychiatry and 2Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, 3Laboratori de Neurofarmacologia, Facultat de Ciènci...
متن کاملNeuropathic pain
Neuropathic pain (NP) is defined as ''pain arising as a direct consequence of any lesion or disease affecting the somatosensory system. " [1,2] Although NP may be an idiopathic process reflecting abnormal sensory processing in the peripheral or central nervous system, it more often appears following physical insult or disease affecting the peripheral or central nervous system. It is likely that...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2014
ISSN: 1662-5102
DOI: 10.3389/fncel.2014.00121